Objectives To conduct pooled estimates and comparative evaluations of safety and efficacy, alongside cost-effectiveness and value-based pricing analyses, for systemic treatments recommended by the National Comprehensive Cancer Network in refractory colorectal cancer. Methods A comprehensive...

Using simulated patients to mimic nine established non-communicable and infectious diseases over 27 trials, we assess ChatGPT's effectiveness and reliability in diagnosing and treating common diseases in low- and middle-income countries. We find ChatGPT's performance varied within a single...

Using simulated patients to mimic nine established non-communicable and infectious diseases over 27 trials, we assess ChatGPT's effectiveness and reliability in diagnosing and treating common diseases in low- and middle-income countries. We find ChatGPT's performance varied within a single...

Over the past decades, US Congress enabled the US Food and Drug Administration (FDA) to facilitate and expedite drug development for serious conditions filling unmet medical needs with five special designations and review pathways: orphan, fast track, accelerated approval, priority review, and...

Im maritimen Raum findet sich eine Vielzahl von Infrastrukturen, die von zentraler Bedeutung für die globalen Energiebeziehungen, das Netz des weltweiten Handels mit Nahrungs- und Düngemitteln und nicht zuletzt den Datenaustausch im Internet sind. Schon immer war das Meer Austragungsort...

Background: For several years, two of the major concerns of logistics managers are (i) the visibility of global supply chains and (ii) the uncertainty in deciding which existing logistics security program is the most appropriate according to the security levels for their organization. This last...

Using simulated patients to mimic nine established non-communicable and infectious diseases over 27 trials, we assess ChatGPT's effectiveness and reliability in diagnosing and treating common diseases in low- and middle-income countries. We find ChatGPT's performance varied within a single...

Using simulated patients to mimic nine established non-communicable and infectious diseases over 27 trials, we assess ChatGPT's effectiveness and reliability in diagnosing and treating common diseases in low- and middle-income countries. We find ChatGPT's performance varied within a single...

Purpose Railways are a well-known example of complex critical infrastructure, incorporating socio-technical systems with humans such as drivers, signallers, maintainers and passengers at the core. The technological evolution including interconnectedness and new ways of interaction lead to new...

Workplace abuse is a widespread, worldwide social phenomenon and the topic is highly germane, given the established link between employment quality and mental and physical health and the changes developing in the labor market, including globalization processes, economic recession influenced by...

The purpose of this Special Issue is to show progress regarding current research and literature on the theme of "Current Trends in Tourism under COVID-19 and Future Implications for Sustainability". In particular, this Special Issue of the peer-reviewed international journal Sustainability...

Replacing car travel with walking and cycling lowers emissions, improves air quality and makes communities healthier. Rates of active travel typically increase when dedicated infrastructure is implemented. But policymakers in multiple countries regularly contend with two obstacles: designing...

We study whether it is socially desirable to hold a monopolistic firm liable for the harm its potentially judgment-proof consumers inflict on third parties. Consumers' judgment-proofness limits potential product differentiation by pooling different consumer types with uniform liability exposure....

Replacing car travel with walking and cycling lowers emissions, improves air quality and makes communities healthier. Rates of active travel typically increase when dedicated infrastructure is implemented. But policymakers in multiple countries regularly contend with two obstacles: designing...

The popularity of tiny houses is increasing, but the technical details are rarely covered. Therefore, this study examines the structural, stability, weight, and thermal requirements of tiny houses. A configurable SolidWorks model was created, and the location and quantity of structural supports...

The restrictions triggered by the COVID-19 pandemic, especially during the first weeks of confinement in 2020, entailed marked changes concerning urban socio-spatial relations. This article analyzes perceptions of the importance of public space, neighbors' support, neighborhood safety, and home...

Background: Over the past decades, US Congress enabled the US Food and Drug Administration (FDA) to facilitate and expedite drug development for serious conditions filling unmet medical needs with five special designations and review pathways: orphan, fast track, accelerated approval, priority...

Workplace abuse is a widespread, worldwide social phenomenon and the topic is highly germane, given the established link between employment quality and mental and physical health and the changes developing in the labor market, including globalization processes, economic recession influenced by...

Purpose: In heavy industries like mining, where safety is paramount, organisations need a well-functioning system of accountability. Yet to whom employees perceive they are accountable differs at varying hierarchical levels. This article reports on the findings from a study that investigated...

Purpose The article presents the phenomenon of hazards related to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in the food supply chain (FSC) by identifying possible stakeholders of a seafood company who might be influenced by the hazards. Design/methodology/approach A case study...