A multiple comparison procedure for hypotheses with gatekeeping structure
We develop gatekeeping procedures that focus on comparing multiple treatments with a control when there are multiple endpoints. Our procedures utilize estimated correlations among individual test statistics without parametric assumptions. We make comparisons with other gatekeeping procedures with respect to properties of the trade-off in statistical power between families of hypotheses. We introduce a reward function to facilitate these comparisons. We illustrate our methods by simulation and an analysis of data from a randomized, multi-armed clinical trial. Copyright 2013, Oxford University Press.
Year of publication: |
2013
|
---|---|
Authors: | Luo, Xiaolong ; Chen, Guang ; Ouyang, S. Peter ; Turnbull, Bruce W. |
Published in: |
Biometrika. - Biometrika Trust, ISSN 0006-3444. - Vol. 100.2013, 2, p. 301-317
|
Publisher: |
Biometrika Trust |
Saved in:
Online Resource
Saved in favorites
Similar items by person
-
Farm mortgage decisions under varying market interest rates
Luo, Xiaolong, (1998)
-
Li, Mingyu, (2012)
-
The Richardson model in a random environment
Luo, Xiaolong, (1992)
- More ...