A permutation test approach to phase II historical control trials

In this note we outline 15 years of Gynecologic Oncology Group (GOG) experience conducting a series of phase II second-line intraperitoneal trials in the treatment of ovarian cancer. Using this information, the goal is to define a new permutation approach to historical control phase II trials in ovarian cancer. We utilize seven previous phase II GOG trials in our database to illustrate our methodology.

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Year of publication:	2009
Authors:	Hutson, Alan ; Markman, Maurie ; Brady, Mark
Published in:	Journal of Applied Statistics. - Taylor & Francis Journals, ISSN 0266-4763. - Vol. 36.2009, 6, p. 589-599
Publisher:	Taylor & Francis Journals
Subject:	clinical trial \| non-randomized

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Extent:	text/html
Type of publication:	Article
Source:	RePEc - Research Papers in Economics

Persistent link: https://www.econbiz.de/10004966832