Cost of illness of breast cancer in low- and middle-income countries : a systematic review

This systematic review explores the cost of illness (COI) studies on breast cancer in low- to middle-income countries (LMICs). Studies in Cochrane, Proquest Thesis, PubMed and Scopus were considered. The reporting criteria were evaluated using the Consolidated Health Economic Evaluation Reporting Standards (CHEERS) 2022 statement. Studies must (1) be peer-reviewed, (2) report cost data, and (3) be full-text articles. Non-English articles were excluded. Twelve studies were included. The identified costs were made constant to 2022 USD values for reporting and comparison across studies. Annual costs per patient varied from $195 to $11,866 direct medical costs, $201 to $2233 direct non-medical costs and $332 to $26,390 productivity losses were reported. Cost differences were due to the cost types and components in each study. Only three COI studies reported sensitivity analysis and discount rates. Hence, it is recommended that future COI studies include an analysis of correlation between cost components and other variables. Highlights • Direct medical costs with hospitalisation were reported as the highest cost of breast cancer among the LMICs. • Direct non-medical costs and productivity losses added to the financial burden of breast cancer patients. • COI studies without sensitivity analysis cannot predict breast cancer outcomes. • Correlation analysis between cost components and other variables in future COI studies could provide more information for decisions on healthcare resource allocation and planning