Genetical and statistical aspects of polymerase chain reactions

In this paper we describe the principles of polymerase chain reaction (PCR) and its expanding use in molecular genetic research and molecular medicine. A short introduction of exemplary applications of the PCR is connected with a discussion of the lack of PCR accuracy. We give a statistical model for the PCR and discuss estimation methods in order to quantify the lack of PCR accuracy.

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Year of publication:	2000
Authors:	Brunnert, Marcus ; Müller, Oliver ; Urfer, Wolfgang
Publisher:	Dortmund : Universität Dortmund, Sonderforschungsbereich 475 - Komplexitätsreduktion in Multivariaten Datenstrukturen
Subject:	Polymerase chain reaction \| lack of PCR accuracy \| branching process \| estimation of the mutation rate

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Series:	Technical Report ; 2000,06
Type of publication:	Book / Working Paper
Type of publication (narrower categories):	Working Paper
Language:	English
Other identifiers:	766701034 [GVK] hdl:10419/77228 [Handle] RePEc:zbw:sfb475:200006 [RePEc]
Source:	EconStor

Persistent link: https://www.econbiz.de/10010316571