Interim analysis of COVID-19 vaccine effectiveness against hospitalisation due to COVID-19 and death using electronic health records in eight European countries : April 2022 to July 2023 : first update

This report presents pooled COVID-19 vaccine effectiveness (VE) estimates for the first, second and third booster doses (compared to complete primary vaccination with no booster) against hospitalisation due to COVID-19 and COVID-19-related death in resident populations ≥50 years of age living in the community in up to eight European countries: Belgium, Denmark, Italy, Luxembourg, Spain (Navarra), Norway, Portugal, and the Netherlands. This study was undertaken within the Vaccine Effectiveness, Burden and Impact Studies (VEBIS) project. Compared to the previous report, this analysis uses the same methodology, extends the study period by four month (up to July 2023) and includes two additional countries. The study period covered in this report is April 2022 to July 2023. The relative VE of the first, second and third booster dose were estimated compared to the effectiveness of complete primary vaccination received at least 24 weeks ago (≥24 weeks).