Multivariate random-effects meta-regression: Updates to mvmeta

An extension of mvmeta, my program for multivariate random-effects meta-analysis, is described. The extension handles meta-regression. Estima- tion methods available are restricted maximum likelihood, maximum likelihood, method of moments, and fixed effects. The program also allows a wider range of models (Riley’s overall correlation model and structured between-studies covari- ance); better estimation (using Mata for speed and correctly allowing for missing data); and new postestimation facilities (I-squared, standard errors and confidence intervals for between-studies standard deviations and correlations, and identifi- cation of the best intervention). The program is illustrated using a multiple- treatments meta-analysis. Copyright 2011 by StataCorp LP.