To examine how mechanistic principles derived in small networks are manifest in larger networks, we developed a versatile neuronal network simulator, NNET, in portable C++ code. NNET allows easy, fast and accurate characterization of any neuronal population and coupling pattern of electrical and...

We measured arm movement on the sagittal plane of parietal lobe damaged patients and normal subjects. In neurological patients, (1) the hand height did not become lower as the motion duration became shorter; (2) the hand jerk of measured trajectory increased when motion duration lengthened; (3)...

Mutual information between stimulus and response has been advocated as an information theoretic measure of a neural system's capability to process information. Once calculated, the result is a single number that supposedly captures the system's information characteristics over the range of...

Conventional electroencephalography (EEG) and magnetoencephalography (MEG) analysis often rely on averaging over multiple trials to extract statistically relevant differences between two or more experimental conditions. We demonstrate that by linearly integrating information over multiple...

Seizure cancellation in a network model with Hodgkin-Huxley type elements was evaluated by applying different stimulation paradigms. The simulated activities of single neurons and a computed field potential during different states of the network were the basis of this evaluation. Three types of...

Different rhythmic activities in CA1 characterize the neuronal correlate of several behavioral states. Recently, in an in vitro preparation of whole hippocampus, generation of spontaneous slow rhythms, similar to in vivo hippocampal EEGs, has been reported. We previously proposed a dynamical...

The detection of weak sensory signals is an important aspect of sensory neuronal processing. Behaviorally relevant signals from the environment are often encoded as perturbations of on- going spiking activity in primary afferents, but little is known about how they are detected when embedded in...

To have a means to have the possibility for a certain period to either choose for or against making an invetsment decision, without binding oneself up front. The real option rule is that one should invest today only if the net present value is high enough to compensate for giving up the value of...

In this paper, we discuss the convergence of two time window discretization methods for vehicle routing problems with time windows. The first method provides a feasible solution for the minimization problem while the second, newly developed by the authors, provides a lower bound. Analysis shows...

The bid valuation and construction problem for carriers facing combinatorial auctions for the procurement of freight transportation contracts is very difficult and involves the computation of a number of NP-hard sub problems. In this paper we examine computationally tractable approxim ation...