Inhibitory interneurons play crucial roles in the regulation of patterns of activity in the hippocampus, and some types are thought to be vulnerable in epilepsy. The connections between excitatory and inhibitory synapses are important for generation of bursting activity in pyramidal neurons. The...

We introduce a new correlation-based measure of spike timing reliability. Unlike other measures, it does not require the definition of "events". It relies on only one parameter, which directly relates to the timescale of spike timing precision. We test the measure in a complex reliability...

A conductance-based model for synaptic transmission and postsynaptic integration reveals that the variability of postsynaptic responses depends on the number of synaptic inputs in a non-linear way. Increasing the number of excitatory and inhibitory inputs increases the total synaptic...

The transfer functions of visual and auditory neurons have been found to adapt to the statistics of the input signals. This adaptation has been suggested to maximize information transmission (Brenner,et al., 2000; Wainwright,1999). However, given only the output of the neuron was monitored in these...

We used a computational model of biochemical pathways that are involved in the phosphorylation/dephosphorylation of AMPA receptor to study the responses of the receptor to calcium oscillations. In the model, the biochemical pathways are assumed to be located immediately under the postsynaptic...

Effects of short-term synaptic plasticity on cell firing properties in a microcircuit formed by a reciprocally connected pyramidal cell and FSN interneuron in layer 2/3 of neocortex were analyzed in a biophysical model. Induction of synaptic depression by backpropagating dendritic action...

To test the hypothesis that gap junctions have a role on electroolfactogram (EOG) oscillations we made two models of olfactory epithelium, one with gap junctions and the other without gap junctions. We gave identical odor stimulus to the two networks and measured their EOG responses. The...

We used a computational model of biochemical pathways that are involved in the phosphorylation/dephosphorylation of AMPA receptor to study the responses of the receptor to calcium oscillations. In the model, the biochemical pathways are assumed to be located immediately under the postsynaptic...

We used a computational model of biochemical pathways that are involved in the phosphorylation/dephosphorylation of AMPA receptor to study the responses of the receptor to calcium oscillations. In the model, the biochemical pathways are assumed to be located immediately under the postsynaptic...

We measured arm movement on the sagittal plane of parietal lobe damaged patients and normal subjects. In neurological patients, (1) the hand height did not become lower as the motion duration became shorter; (2) the hand jerk of measured trajectory increased when motion duration lengthened; (3)...