This document contains the validation report of the H. azteca bioconcentration test (HYBIT), prepared by Germany in 2023 and approved as Test Guideline 321 by the Working Party of the National Coordinators of the Test Guidelines Programme. This was a project on the work plan of the Test...

This document contains a Guidance Document (GD) on Integrated Approaches to Testing and Assessment (IATA) for Phototoxicity Testing, originally developed by Japan, reviewed, consolidated and finally approved by the Working Party of the National Coordinators of the Test Guidelines Programme. This...

This document contains the validation report of the IL-2 Luc LTT assay on in vitro immunotoxicity, prepared by Japan in 2023. This was a project on the work plan of the Test Guidelines Programme until 2024.

This document contains the Performance Standards (PS) for the assessment of proposed in vitro assays, similar to the in vitro Epidermal Sensitisation Assay (EpiSensA), or modified. The EpiSensA is an in vitro method for identifying the skin sensitisation potential of chemicals. The EpiSensA...

This document contains the report of the peer review organised by Japan for the validation of the IL-2 Luc LTT assay on in vitro immunotoxicity, a project on the work plan of the Test Guidelines Programme until 2024.

This document presents the design and the results of a validation exercise for the short-term Juvenile Hormone Activity Screening Assay (JHASA) using Daphnia magna, organised by Japan. This method was developed to detect the potential endocrine disrupting chemicals (EDCs) with juvenile hormone...

This document describes the design and results of the validation exercise for the Rapid Estrogen ACTivity In Vivo (REACTIV) Assay, organised by France and the United Kingdom. This method was developed for the detection of estrogen axis active substances. The project was on the Test Guidelines...

The objective of the Integrated Approaches for Testing and Assessment (IATA) Case Studies Project is to increase experience with the use of IATA by developing case studies which constitute examples of predictions that are fit for regulatory use. The aim of this project is to create common...

This document encloses the Peer Review Report (PRR) of the validation study for OptiSafeTM Eye Irritation Test (EIT) for its inclusion in OECD Test Guideline 496 on In Vitro Macromolecular Test Methods. The OptiSafeTM EIT is validated for identifying chemicals that do not require classification...

The report relates to discussions held on operational and financial aspects of test methods validation under the OECD Test Guidelines Programme. The workshop was organised in the context of a broader discussion on building confidence of regulatory bodies and modernising the validation process...