Many computer algorithms have been developed to construct experimental designs that are D-optimum for the fixed parameters of a statistical model. However, the case when the interest is in the variance components has not received much attention. This problem has similarities with that of...

In dose-response studies, the dose range is often restricted due to ethics concerns over drug toxicity and/or efficacy, particularly when human subjects are involved. We present locally optimal designs for the estimation of several percentiles simultaneously on restricted as well as unrestricted...

In dose-response studies, the dose range is often restricted due to ethics concerns over drug toxicity and/or efficacy, particularly when human subjects are involved. We present locally optimal designs for the estimation of several percentiles simultaneously on restricted as well as unrestricted...

This paper considers a life test under progressive type I group censoring with a Weibull failure time distribution. The maximum likelihood method is used to derive the estimators of the parameters of the failure time distribution. In practice, several variables, such as the number of test units,...

Rearranging the sequence of test treatments and control treatment within each block of an A-optimal balanced treatment block design such that certain conditions are satisfied, the resulting design is an A-optimal repeated measurements designs when blocks are regarded as units or periods. The...