We construct efficient designs for the Michaelis-Menten enzyme kinetic model capable of checking model assumption. An extended model, called EMAX model is also considered for this purpose. This model is widely used in pharmacokinetics and reduces to the Michaelis- Menten model for a specific...

We construct efficient designs for the Michaelis-Menten enzyme kinetic model capable of checking model assumption. An extended model, called EMAX model is also considered for this purpose. This model is widely used in pharmacokinetics and reduces to the Michaelis- Menten model for a specific...

This paper comparatively evaluates performances of widely-used filters employed to separate the trend of a given non-stationary time series from its cyclical components, against a Chebyshev polynomial-based filter designed for this purpose. The performances of detrending techniques under...

A computational method based on Chebyshev spectral method is presented to solve the linear–quadratic optimal control problem subject to terminal state equality constraints and state-control inequality constraints. The method approximates each of the system state variables and each of the...