In this article we propose a new approach in event studies based on a hidden Markov chain combined with a classical event study model. The number of states informs us about the number of significant events affecting the related market, and the identification of the hidden states determines...

In this article we propose a new approach in event studies based on a hidden Markov chain combined with a classical event study model. The number of states informs us about the number of significant events affecting the related market, and the identification of the hidden states determines...

Translational research studies often involve a central study (e.g. clinical trial, cohort of patients, etc.) and multiple investigators who are each interested in addressing different research questions using the same patient population. However, it is often impossible for the investigators to...

The determination of toxicokinetic parameters is an essential component in the risk assessment of potential harmful chemicals. It’s a first step to analyse the processes which are involved in the development of DNA adducts and might therefore lead to the development of cancer. The complete...

A mixture model for long-term survivors has been adopted in various fields such as biostatistics and criminology where some individuals may never experience the type of failure under study. It is directly applicable in situations where the only information available from follow-up on individuals...

The determination of toxicokinetic parameters is an essential component in the risk assessment of potential harmful chemicals. It’s a first step to analyse the processes which are involved in the development of DNA adducts and might therefore lead to the development of cancer. The complete...