The field of cost-effectiveness analysis (CEA) deals with the comparison of healthinterventions based on both costs and effectiveness (ability to improve health). Thisdissertation makes several methodological contributions to this area.Part I develops direct methods for computing mean costs and...

The first essay considers a service center with two stations in accordance with independent Poisson processes. Service times at either station follow the same general distribution, are independent of each other and are independent of the arrival process. The system is charged station-dependent...

In the current economic climate, many companies are facing pressures to operate more efficiently resulting in frequent mergers, acquisitions, and reorganizations. This often necessitates a change in various network structures within these organizations, which leads to the guiding question of...

Assortment planning and pricing are among the most important strategic questions for many firms. These decisions are particularly challenging when inventory considerations need to be taken into account. Unfortunately, the trade-offs created by the assortment, pricing and inventory decisions are...

This dissertation discusses substitution effects on retail pricing problems. In the presence of substitutable products, the inventory levels and prices of different products interact in complicated ways and, therefore, insights developed in the context of single-product pricing problems do not...

Companies in a broad range of industries and economies rely heavily on external sources to finance their operations. But, external financing could be expensive and/or difficult to obtain due to imperfections in real capital markets. I focus on cash-constrained manufacturers that rely on external...

We consider a make-to-order production system where two major components, one nonperishable (referred to as part 1) and one perishable (part 2), are needed to fulfill a customer order. In each period, replenishment decisions for both parts need to be made jointly before demand is realized and a...

This dissertation examines global groups at work through an intensive study of cross-national student teams and case studies of exemplar companies that work across boundaries. We consider the role of transactive memory systems (TMS) as a way to create effective team processes. A TMS is a...

The work of this dissertation is concerned with the study of the effectiveness ofparadigms of production flexibility to either improve system performance or mitigatesystem risk. A brief introduction to the concept of operational flexibility is provided inChapter I. In Chapter II, we consider a...

In the extant supply-risk management literature, most research assumes the manufacturer is as knowledgeable about supply disruption risk as its suppliers. In practice, however, a supplier often has better information about its likelihood of experiencing a disruption than the manufacturer it...