We develop a deep reinforcement learning (RL) framework for an optimal market-making (MM) trading problem, specifically focusing on price processes with semi-Markov and Hawkes Jump-Diffusion dynamics. We begin by discussing the basics of RL and the deep RL framework used; we deployed the...

Different types of mathematical models can be used to forecast the development of diseases as well as associated costs and analyse the cost-effectiveness of interventions. The set of models available to assess these parameters, reach from simple independent equations to highly complex...

Background As the number of randomized clinical trials (RCTs) demonstrating the survival benefits of combination therapies in previously treated multiple myeloma (MM) patients increases, it is essential to determine the most cost- effective treatment through robust economic evaluation. This...

At the start of the Coronavirus Disease (COVID-19) vaccination campaign in Mexico, the vaccine was the world's most essential and scarce asset. Managing its administration to optimize its use was, and still is, of paramount importance. However, when the first vaccine was developed at the end of...