In proton therapy treatment planning, the aim is to ensure tumour control while sparing the various surrounding risk structures. The biological effect of the irradiation depends on both physical dose and linear energy transfer (LET). In order to include LET alongside physical dose in plan...

A variety of approaches has been developed to deal with uncertain optimization problems. Often, they start with a given set of uncertainties and then try to minimize the influence of these uncertainties. The reverse view is to first set a budget for the price one is willing to pay and then find...

In multi-criteria optimization problems that originate from real-world decision making tasks, we often find the following structure: There is an underlying continuous, possibly even convex model for the multiple outcome measures depending on the design variables, but these outcomes are...

Recursively identified vector autoregressive (VAR) models often lead to a counterintuitive response of prices (and output) shortly after a monetary policy shock. To overcome this problem, we propose to estimate the VAR parameters under the restriction that economic theory is not violated, while...

Recursively identified vector autoregressive (VAR) models often lead to a counterintuitive response of prices (and output) shortly after a monetary policy shock. To overcome this problem, we propose to estimate the VAR parameters under the restriction that economic theory is not violated, while...

Recursively identified vector autoregressive (VAR) models often lead to a counterintuitive response of prices (and output) shortly after a monetary policy shock. To overcome this problem, we propose to estimate the VAR parameters under the restriction that economic theory is not violated, while...