Search Results - subject:"single nucleotide polymorphism"

Innovative difference based on genetic distance model : an empirical analysis of technology innovation

Xiao, Zhenhong; Kim, Kwanghun; Ri, Kumchol - In: International journal of technology management : IJTM 88 (2022) 1, pp. 34-50

Persistent link: https://www.econbiz.de/10013258050

MSDC-0160 and MSDC-0602 Binding with Human Mitochondrial Pyruvate Carrier (MPC) 1 and 2 Heterodimer: PPARγ Activating and Sparing TZDs as Therapeutics

Dugan, Jason L; Bourdon, Allen K; Phelix, Clyde F.; … - In: International Journal of Knowledge Discovery in … 7 (2017) 2, pp. 43-67

The mitochondrial pyruvate carrier (MPC) is a novel target for therapeutic drugs to treat Alzheimer's and Parkinson's disease, diabetes mellitus, and non-alcoholic steatohepatitis (NASH). Metabolic Solutions Development Company (MSDC) has two thiazolidinediones, MSDC-0160 and MSDC-0602, in the...

Persistent link: https://www.econbiz.de/10012046210

M-regression, false discovery rates and outlier detection with application to genetic association studies

Lourenço, V.M.; Pires, A.M. - In: Computational Statistics & Data Analysis 78 (2014) C, pp. 33-42

Robust multiple linear regression methods are valuable tools when underlying classical assumptions are not completely fulfilled. In this setting, robust methods ensure that the analysis is not significantly disturbed by any outlying observation. However, knowledge of these observations may be...

Persistent link: https://www.econbiz.de/10010785333

Estimation of N-acetyltransferase 2 haplotypes

Bolt, Hermann M.; Dannappel, Doris; Blaszkewicz, Meinolf; … - 2006

N-Acetyltransferase 2 (NAT2) genotyping may result in a considerable percentage in several ambiguous allele combinations. PHASE 2.1 is a statistical program which is designed to estimate the probability of different allele combinations. We have investigated haplotypes of 2088 subjects genotyped...

Persistent link: https://www.econbiz.de/10010296730

Selinski, Silvia - 2006

nucleotide polymorphic (SNP) loci and exogenous risk factors. A single nucleotide polymorphism is a point mutation that is …

Persistent link: https://www.econbiz.de/10010296739

Identification of SNP interactions using logic regression

Schwender, Holger; Ickstadt, Katja - 2006

Interactions of single nucleotide polymorphisms (SNPs) are assumed to be responsible for complex diseases such as sporadic breast cancer. Important goals of studies concerned with such genetic data are thus to identify combinations of SNPs that lead to a higher risk of developing a disease and...

Persistent link: https://www.econbiz.de/10010296746

Estimation of N-acetyltransferase 2 haplotypes

Bolt, Hermann M.; Dannappel, Doris; Blaszkewicz, Meinolf; … - Institut für Wirtschafts- und Sozialstatistik, … - 2006

Persistent link: https://www.econbiz.de/10009216867

Identification of SNP interactions using logic regression

Schwender, Holger; Ickstadt, Katja - Institut für Wirtschafts- und Sozialstatistik, … - 2006

Persistent link: https://www.econbiz.de/10009219818

Selinski, Silvia - Institut für Wirtschafts- und Sozialstatistik, … - 2006

nucleotide polymorphic (SNP) loci and exogenous risk factors. A single nucleotide polymorphism is a point mutation that is …

Persistent link: https://www.econbiz.de/10009219836

Association tests through combining p-values for case control genome-wide association studies

Chen, Zhongxue - In: Statistics & Probability Letters 83 (2013) 8, pp. 1854-1862

To detect single nucleotide polymorphisms (SNPs) that are associated with a common disease in a case control genome-wide association study (GWAS), powerful yet robust tests are desirable. Current available robust approaches in this area are mainly based on the optimal trend tests for some...

Persistent link: https://www.econbiz.de/10010678718