Abstract Standard causal mediation analysis decomposes the total effect into a direct effect and an indirect effect in settings with only one single mediator. Under the settings with multiple mediators, all mediators are often treated as one single block of mediators. The effect mediated by a...

Abstract The management of chronic conditions is characterized by frequent re-assessment of therapy decisions in response to the patient’s changing condition over the course of the illness. Evidence most suitable to inform care thus often concerns the contrast of adaptive treatment strategies...