Purpose The traditional drug development process is costly, time consuming and risky. Using computational methods to discover drug repositioning opportunities is a promising and efficient strategy in the era of big data. The explosive growth of large-scale genomic, phenotypic data and all kinds...

In this paper the authors build on prior literature to develop an adaptive and time-varying metadata-enabled dynamic topic model (mDTM) and apply it to a large Weibo dataset using an online Gibbs sampler for parameter estimation. Their approach simultaneously captures the maximum number of...

Solar radiation through glazing area is one major source of the space cooling load in subtropical cooling-dominant climates. Application of energy-efficient glazing system can significantly reduce the energy consumption of air-conditioning systems in summer, thus has become a hot research topic....

Although traditional methods of liquefaction mitigation have been widely applied in engineering practice, some prominent problems remain such as limits on the size of the treated areas, disturbance of existing structures sensitive to deformation or vibration, and environmental impact. In terms...

Liquefaction can result in the damage or collapse of structures during an earthquake and can therefore be a great threat to life and property. Many site investigations of liquefaction disasters are needed to study the large-scale deformation and flow mechanisms of liquefied soils that can be...

In the 2008 Wenchuan earthquake in Sichuan Province, a large number of buildings, water conservancy facilities, and transportation facilities were severely damaged. The damage caused by liquefaction and earthquake-induced soil subsidence was widely distributed, diverse, and extensive. Typical...

Earthquake-induced landslides can cause a large number of casualties and great economic loss. Presently, research methods for studying landslides are largely based on a framework of solid mechanics. In this work, visualization software, known as Visual SPH, is developed in Visual Basic 6.0, and...

To overcome the disadvantages of traditional flow analysis methods for liquefied soils that exhibit fluidization and large deformation characteristics, Smoothed particle hydrodynamics (SPH) is adopted in this study to analyze the flow processes of liquefied soils. Bingham model with the use of...

Flow slides in municipal solid waste (MSW) dumps have caused serious damage to structures and casualties all over the world. Therefore, much attention should be paid to this type of disaster to elucidate the flow mechanisms and fluidization characteristics of MSW, which are essential for the...