A class of self-designing clinical trials is considered which according to an effective but simple, finite learning algorithm consists of automatically adaptively planned weighted group sequential trials with a decision about rejection of the null-hypothesis at each step, but the full...

In many fields of applications, test statistics are obtained by combining estimates from several experiments, studies or centres of a multicentre trial. The commonly used test procedure to judge the evidence of a common overall effect can result in a considerable overestimation of the...