From noisy observations of a finite family of functions an approximation in a lower dimensional space can be constructed using the method of principal components. If certain restrictions are to be satisfied by the approximation, e.g. being densities, this leads to a modified estimation...

We suggest two improved methods for conditional density estimation. The rst is based on locally tting a log-linear model, and is in the spirit of recent work on locally parametric techniques in density estimation. The second method is a constrained local polynomial estimator. Both methods always...

Due to the advent of high-throughput genomic technology, it has become possible to globally monitor cellular activities on a genomewide basis. With these new methods, scientists can begin to address important biological questions. One such question involves the identification of replication...