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Genotype imputation methods are now being widely used in the analysis of genome-wide association studies. Most imputation analyses to date have used the HapMap as a reference dataset, but new reference panels (such as controls genotyped on multiple SNP chips and densely typed samples from the...
Persistent link: https://www.econbiz.de/10009480470
We present methods to estimate marginal utility and marginal product functions that are nonadditive in the unobservable … random terms, using observations from a single hedonic equilibrium market. We show that nonadditive marginal utility and … nonadditive marginal product functions are capable of generating equilibria that exhibit bunching, as well as other types of …
Persistent link: https://www.econbiz.de/10008541328
A number of factors have been proposed that may affect the capacity for an evolutionary system to generate adaptation. One that has received little recent attention among biologists is linkage patterns, or the ordering of genes on chromosomes. In this study, a simple model of genetic...
Persistent link: https://www.econbiz.de/10005790658
Redundant gene functions are ubiquitous, and they are a potentially important source of evolutionary innovations on the biochemical level. It is therefore highly desirable to understand the mechanisms governing their evolution. Gene duplication is clearly a prominent mechanism generating...
Persistent link: https://www.econbiz.de/10005790837
In this study, we define a chi-square random field on a multi-dimensional lattice points index set with a direct product covariance structure and consider the distribution of the maximum of this random field. We provide two approximate formulas for the upper tail probability of the distribution...
Persistent link: https://www.econbiz.de/10011000058
We define and investigate classes of statistical models for the analysis of associations between variables, some of which are qualitative and some quantitative. In the cases where only one kind of variables is present, the models are well-known models for either contingency tables or covariance...
Persistent link: https://www.econbiz.de/10009441395
This thesis is a study of the detection of separation among the sample points in binary logistic regression models. We propose a new algorithm for detecting separation and demonstrate empirically that it can be computed fast enough to be used routinely as part of the fitting process for logistic...
Persistent link: https://www.econbiz.de/10009441572
thepotential for interaction between the parametrically and nonparametrically modeledvariables. We derived a generalized likelihood …
Persistent link: https://www.econbiz.de/10009464885
We introduce mass spectrometry proteomic research for diagnosis from a clinical perspective, with special reference to early-stage breast cancer detection. The nature of SELDI and MALDI mass spectrometric measurement is discussed. We explain how the mass spectral data arising from this...
Persistent link: https://www.econbiz.de/10005752571