Alzheimer's disease (AD) disproportionately burdens racial and ethnic minority populations, yet the extent to which US clinical trials reflect this burden remains poorly understood. We conduct a systematic review of all 88 completed US-based Phase III AD drug trials between 1997 and 2023, using...

Alzheimer's disease (AD) disproportionately burdens racial and ethnic minority populations, yet the extent to which US clinical trials reflect this burden remains poorly understood. We conduct a systematic review of all 88 completed US-based Phase III AD drug trials between 1997 and 2023, using...

The influence of genetic risk on dementia can be shaped by social environments. Following older adults without dementia at baseline for 12 years in two large cohorts - Health and Retirement Study (HRS) and English Longitudinal Study of Ageing (ELSA), we examine how APOE alleles interact with...

While most dementia prevention strategies and risk prediction models emphasize biomedical and genetic factors, the influence of genetic risk on dementia also appears shaped by social environments. Following older adults without dementia at baseline for up to 12 years in two large cohort...

Assistance with daily activities is crucial for persons living with dementia and disabilities, yet many face significant challenges in accessing adequate care and support. Using harmonized longitudinal survey data (2012-2018) from the United States, England, 18 European countries and Israel, and...

This study examines the relationship between the number of children and dementia risk among parents, addressing longstanding questions about how parenthood shapes cognitive health in later life. Using comprehensive administrative data on all parents born in Sweden between 1920 and 1950, along...

Assistance with daily activities is crucial for persons living with dementia and disabilities, yet many face significant challenges in accessing adequate care and support. Using harmonized longitudinal survey data (2012-2018) from the United States, England, 18 European countries and Israel, and...

Dementia is associated with an increasing need for care, which is often provided by informal carers. This may have an impact on their behaviour in the labour market. This study analyses the impact of dementia severity on informal care, labour market participation and working hours of informal...

We provide causal evidence that patient peer effects generate mortality impacts comparable to provider quality differences. Drawing on administrative records covering 2.6 million stays (2000 - 2010) across 7,200 U.S. nursing homes, we exploit plausibly exogenous roommate assignments identified...

Cognitive impairment poses considerable challenges among older adults, with the protective role of family support becoming increasingly crucial. This study examines the role of children's residential proximity and spousal presence with dementia risk in cognitively impaired older adults. We...

Cognitive impairment poses considerable challenges among older adults, with the protective role of family support becoming increasingly crucial. This study examines the role of children's residential proximity and spousal presence with dementia risk in cognitively impaired older adults. We...

Low healthcare quality has been found to predict the development of several illnesses in older adults, while the evidence on dementia is still lacking. This study assesses whether and to what extent experiencing low healthcare quality can be associated with developing dementia in people...

Low healthcare quality has been found to predict the development of several illnesses in older adults, while the evidence on dementia is still lacking. This study assesses whether and to what extent experiencing low healthcare quality can be associated with developing dementia in people...

Disparities in cognition persist between non-Hispanic Black (hereafter, Black) and non-Hispanic White (hereafter, White) older adults, and are possibly influenced by early educational differences stemming from structural racism. However, the relationship between school racial segregation and...

Disparities in cognition persist between non-Hispanic Black (hereafter, Black) and non-Hispanic White (hereafter, White) older adults, and are possibly influenced by early educational differences stemming from structural racism. However, the relationship between school racial segregation and...

Existing evidence suggests that wealth may decline before dementia onset, but the mechanisms underlying these reductions are poorly understood. Using longitudinal data from the Health and Retirement Study, we compare household finance trajectories for individuals who later develop dementia and...

We use population-wide administrative data from Denmark and an event-study design spanning nearly two decades to examine the impact of having a parent with dementia on adult children's labor market, physical health, and mental health outcomes. We find no meaningful effects on labor supply,...

The Medicare hospice program is intended to provide palliative care to terminal patients, but patients with long stays in hospice are highly profitable, motivating concerns about overuse among the Alzheimer's and Dementia (ADRD) population in the rapidly growing for-profit sector. We provide the...

We provide causal evidence that patient peer effects generate mortality impacts comparable to provider quality differences. Drawing on administrative records covering 2.6 million stays (2000-2010) across 7,200 U.S. nursing homes, we exploit plausibly exogenous roommate assignments identified...

Sogenannte Volkskrankheiten führen nicht nur zu Sorge und Leid bei den unmittelbar Betroffenen. Sie haben auch Auswirkungen auf sozialer, politischer und wirtschaftlicher Ebene. Gerade dem Zusammenhang mit ökonomischen Faktoren wurde bislang aber erstaunlich wenig Aufmerksamkeit geschenkt. Der...

Background: Junior medical doctors have a key role in discussions and decisions about treatment and end-of-life care for people with dementia in hospital. Little is known about junior doctors’ decision-making processes when treating people with dementia who have advance care directives (ACDs),...

"Sustainable Development Goals (SDGs) aim to develop a better and sustainable future for the world and the goals are part of an action plan to address poverty, hunger, health, gender equity and various pressing world issues. One of these goals looks at health and wellness. Ageing populations...

Purpose: Since the enactment of the long-term care insurance (LTCI) act in 2000, the number of LTCI users has increased annually. However, evidence regarding what is being carried out as rehabilitation treatment under LTCI is lacking. In this study, a scoping review was performed to bridge this...