From an Latin American perspective, a framework has been developed with input from social studies of technology (SST) and the complex systems evolutionary economics (EE) to address issues related to innovation processes, technological change and development in this region. The framework operates under assumptions of middle-range theory, bounded field-oriented problems, making combinations of concepts and generating an explanatory framework. The framework states: simplicity in the selection of concepts (convergent), specificity to understand and describe the dynamics, trajectory, joints and configurations of socio-technical systems of production and innovation. Finally, it provides a perspective of generality and scope, an explanatory model (medium range) that incorporates the contributions of empirical research generated in the political debate about development in the region. Raised in the working paper presented in paragraph 1, the contributions of the social studies of technology and evolutionary economics of complex systems to be used in the framework. Paragraph 2 sets out the key concepts of the framework and the connection between them, together with the assumptions that structure it. In section 3 describes the concepts in the context of the functioning of socio-technical systems of production and innovation. Then as a closure raises some issues to address research problems specific to the Latin American context, where you can apply the methodological framework and the implications thereof.