A Computer Model to Analyse the Cost-Effectiveness of Hormone Replacement Therapy - a Revised Version

This report presents a computer model for evaluating the cost-effectiveness (CE) of Hormone Replacement Therapy (HRT). The model is an extension of a previous model and includes also the risk of spine and wrist fracture. New Swedish data on risk of coronary heart disease and related mortality are included. The report describes the model's structure and data requirements; it also investigates the impact on the CE results by using the new model and by adding the wrist and spine fractures to the model. We further investigate whether the results are sensitive to the inclusion of Swedish risk and mortality data for CHD instead of using data based on the Framingham study. The results show that the incremental cost-effectiveness ratios (ICERs) are insensitive to the chosen model, to the assumption that the risk of wrist and spine fracture follows that of hip fracture, and to replacing the Framingham data with Swedish CHD risk and mortality data