Ag Doped Co/Ni Bimetallic Organic Framework for Determination of Luteolin

Electrochemical determination of luteolin is vital to food industry owing to its bioactive properties such as anti-viral, anti-ulcer, while bare electrode of traditional electrochemical sensors generally have narrow linear range and low sensitivity, limiting their practical application. Accordingly, a new nano-architecture fabricated with Ag dopped 3D-CoNi-MOF is firstly developed as an electrochemical material for electrochemical determination of luteolin. The introduction of Ag to 3D flower-like hierarchical structure greatly increase specific surface area and electrical conductivity, which subsequently provides more excellent active sites for luteolin oxidation. Under optimal conditions, Ag-CoNi-MOF sensor present a broader linear response to luteolin concentration of 0.002 – 1.0 μM with a detection limit as low as 0.4 nM (S/N = 3). Ag-CoNi-MOF has good anti-interference according to comparative amperometric current response of luteolin within different organic analytes and metal ions. Finally, the sensor platform is implemented directly to determine luteolin in human urine for evaluation of its practical application. Above all, Ag-CoNi-MOF sensors fabricated performs larger linear range with high sensitivity and anti-interference properties, providing a potential strategy for electrochemical determination of luteolin