This report presents the final results of the study named AVEMAC (Assessing Agriculture Vulnerabilities for the design of Effective Measures for Adaptation to Climate Change). This study has been realized in collaboration of the Actions AGRI4CAST, GeoCAP, AGRI0ENV, and AGRITRADE of the Institute for Environment and Sustainability (IES) and the Institute for Prospective Technological Studies (IPTS) within the European Commission’s Joint Research Centre. The motivation of this study has been the lack of information on vulnerabilities, risks, and needs for the adaptation of European agriculture under a changing climate in the next decades. Directorate0General for Agriculture and Rural Development (DG AGRI) therefore asked the scientific support of the Joint Research Centre to conduct this study in order to present the existing knowledge through mapping and characterizing the vulnerabilities of EU agricultural systems to climate change, to come up with a methodological framework and to propose follow0up actions. Eventually the results of this study shall help the formulation of appropriate policy options and the development of adequate policy instruments to support the adaptation to climate change of the EU agricultural sector.