Biodiversity : New Leads for the Pharmaceutical and Agrochemical Industries

Biodiversity -- Contents -- 1 Natural Products - History, Diversity and Discovery -- Microbial Natural Products: A Past with a Future -- New Concepts and Approaches to Biodiversity -- Natural Products Drug Discovery at the National Cancer Institute. Past Achievements and New Directions for the New Millennium -- Secondary Metabolites as a Vital Source of Animal Health Products -- The Relationship Between Natural Products and Synthetic Chemistry in the Discovery Process -- Natural Products vs. Combinatorials: A Case Study -- 2 Microbial Natural Products Discovery -- Mushrooms, Microbes and Medicines -- Signal Transduction Inhibitors from Microorganisms -- Novel Inhibitors of Lipoprotein Associated Phospholipase A2 Produced by Pseudomonas fluorescens DSM 11579 -- 3 Marine Natural Products -- Marine Organisms as a Source of Novel Lead Structures for Drug Development -- The Anticancer Dolastatins as Cyanobacterial Metabolites -- A Cu2+ Selective Marine Metabolite -- 4 Plant Natural Products -- Water Soluble Bioactive Alkaloids -- 'Lessons from Nature': Can Ecology Provide New Leads in the Search for Novel Bioactive Chemicals from Tropical Rainforests? -- Brazilian Biodiversity: A Source of Phytomedicines, Natural Drugs and Leads for the Pharmaceutical and Agrochemical Industries -- A Modern Perspective to the Traditional Use of Plants in the Highlands of Scotland -- 5 Biosynthesis -- In Vivo and In Vitro Biosynthetic Studies: Understanding and Exploiting Natural Pathways -- Fused Ring Aromatic Polyketides are Formed by Different Cyclisation Pathways in Fungi and Streptomycetes -- 6 Natural Products as Leads for Synthesis -- The Strobilurin Fungicides - From Mushroom to Molecule to Market -- A Synthesis of (+)-Prelog-Djerassi Lactonic Acid -- N-(α-Aminoacyl)-5'-O-Sulfamoyladenosines: Natural Product Based Inhibitors of Amino Acyl tRNA Synthetases.