Desynchronization of Rhythmic Burst Activity in a Simulated Neural Network

Seizure cancellation in a network model with Hodgkin-Huxley type elements was evaluated by applying different stimulation paradigms. The simulated activities of single neurons and a computed field potential during different states of the network were the basis of this evaluation. Three types of electrostimulation were investigated: hyperpolarization of the neurons, depolarization, and an electric stimulus that is proportional to the inverted field potential. We demonstrated that a seizure, represented by synchronized network activity, and consequently a large amplitude field potential, could be effectively stopped by the third type of stimulus. The depolarization and hyperpolarization paradigms failed to desynchronize the activities