EFFECTS OF SELECTIVE ADVANTAGE OF HbS OVER HbA IN THE TRANSMISSION DYNAMICS OF SICKLE CELL ANAEMIA

Despite rising concern over the biology of Sickle Cell Anaemia (SCA), no general modeling approach has considered the effects of the selective advantage of Haemoglobin S (HbS) over Haemoglobin (HbA). This paper develops a theoretical framework and demonstrates mathematically that mating between the three different genotypic groups, namely: normal AA, carriers AS and sicklers SS, does not yield equal probabilities of having neonates of these classes.

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Year of publication:	2005
Authors:	TCHUENCHE, JEAN M.
Published in:	Advances in Complex Systems (ACS). - World Scientific Publishing Co. Pte. Ltd., ISSN 1793-6802. - Vol. 08.2005, 01, p. 1-5
Publisher:	World Scientific Publishing Co. Pte. Ltd.
Subject:	Selective advantage \| transmission dynamics \| renewal equation \| Sickle Cell Anaemia

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Extent:	application/pdf text/html
Type of publication:	Article
Source:	RePEc - Research Papers in Economics

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