Evolving solvent contexts in protein folding: modeling the self-protecting chain

We simulate ab initio the folding of protein chains using a topological predictive algorithm in which conformation-dependent environments are shown to be determined by 3-body correlations. Such correlations protect intramolecular hydrogen bonds from water attack and induce cooperativity.

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Year of publication:	2002
Authors:	Fernández, Ariel
Published in:	Physica A: Statistical Mechanics and its Applications. - Elsevier, ISSN 0378-4371. - Vol. 308.2002, 1, p. 80-88
Publisher:	Elsevier
Subject:	Protein folding \| Ab-initio folding simulations \| Kosmotrope \| Backbone desolvation \| Solvophobic effect

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Type of publication:	Article
Source:	RePEc - Research Papers in Economics

Persistent link: https://www.econbiz.de/10011064054