This paper contributes to the emerging literature on gender differences in the causes and consequences of brain drain. Differentiating between gender bias in the access to economic opportunities and gender differentials in economic outcomes, we find that differences in access have a significant impact on the emigration of highly-skilled women relative to that of men. However, differentials in outcomes do not have a significant impact. Additionally, the structure of political institutions in the source countries does not have a significant impact on the difference in emigration rates.