Novel Numerical Method for Isolation of Different Components within a Complex Current Traces

In many neurophysiological studies researchers must separate different parts of complex currents. To reveal different components of currents they usually use the application of pharmacological substances. But in some cases, method of pharmacological separation may be not ideal due to insufficient selectivity of blockers. Also if one needs to investigate modulation of more than one component, many additional blocking schedules must be utilised depending on the number of components that need to be investigated.We suggest a method that allows to separate any number of steady current components by a combination of least squares and gradient algorithms