Research on Rare Earth Doped Mesoporous Bioactive Glass Nano Sphere S.Ⅰ. Similarity of in Vitro Biological Effects

Rare earth (RE) elements, known as "industrial vitamins," are widely used in advanced materials to optimize their properties. In this work, RE (La, Ce, Pr, Nd, Eu and Dy) - doped mesoporous bioactive glass nanospheres (RE/MBG) were synthesized using the sol-gel method. It was proven for the first time that the homology of RE ions confers functional similarity in bone tissue engineering, and the desired properties are obtained by guiding cell behavior and changing the physicochemical properties of biomaterials. It was found that RE/MBG nanospheres have similar structures and therefore similar properties, such as sustained drug release and anticancer properties, and are pH - and time - dependent. This study provides a feasible strategy for the development, evaluation and basic research of homologous group ion-doped nanobiomaterials in bone tissue engineering