Statistical Inference in Evolutionary Models of DNA Sequences via the EM Algorithm

We describe statistical inference in continuous time Markov processes of DNA sequences related by a phylogenetic tree. The maximum likelihood estimator can be found by the expectation maximization (EM) algorithm and an expression for the information matrix is also derived. We provide explicit analytical solutions for the EM algorithm and information matrix.

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Year of publication:	2007
Authors:	Hobolth, Asger ; Jensen, Jens
Published in:	Statistical Applications in Genetics and Molecular Biology. - Berkeley Electronic Press. - Vol. 4.2007, 1, p. 18-18
Publisher:	Berkeley Electronic Press
Subject:	continuous time Markov chain \| EM algorithm \| information matrix \| likelihood inference \| molecular evolution

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Extent:	application/pdf
Type of publication:	Article
Notes:	oai:bepress:
Source:	RePEc - Research Papers in Economics

Persistent link: https://www.econbiz.de/10005585061