This paper proposes the application of the multidimensional partial differentiation theoretical framework on sciences and social sciences. The idea is to show that is possible to apply a large number of partial derivatives simultaneously into different dimensions (or graphical spaces). It is to observe the infinitesimal changes happen between a large serial of multi-dependent and multi-independent variables from different functions that are displayed into different graphical spaces or dimensions. Hence, the multidimensional partial differentiation requests the application of the "Mega-Space Coordinate System" to support the analysis and visualization of a large number of functions that applied partial differentiation in different graphical spaces or dimensions