A mixed effects least squares support vector machine (LS-SVM) classifier is introduced to extend the standard LS-SVM classifier for handling longitudinal data. The mixed effects LS-SVM model contains a random intercept and allows to classify highly unbalanced data, in the sense that there is an...

For personalised medicine the identification of predictive biomarkers is of great interest. These could guide the choice of therapy and could therefore optimise the benefits of patients of such treatments. The technology of gene expression microarrays allows one to scan thousands of potentially...

Most probability-based methods used to link records from two distinct data sets corresponding to the same target population do not lead to perfect linkage, i.e. there are linkage errors in the merged data. Further, the linkage is often incomplete, in the sense that many records in the two data...

This paper proposes a linear quantile regression analysis method for longitudinal data that combines the between- and within-subject estimating functions, which incorporates the correlations between repeated measurements. Therefore, the proposed method results in more efficient parameter...

Linear mixed-effects models involve fixed effects, random effects and covariance structures, which require model selection to simplify a model and to enhance its interpretability and predictability. In this article, we develop, in the context of linear mixed-effects models, the generalized...

Recent research shows that the inclusion of choice related demo- and sociographics in discrete choice models aids in modeling the choice behavior of consumers substantially. However, the increase in efficiency gained by accounting for covariates in the design of a choice experiment has thus far...

A wavelet-based method is proposed to obtain accurate estimates of curves in more than one dimension and of their derivatives. By means of simulation studies, this novel method is compared to another locally-adaptive estimation technique for multidimensional functional data, based on free-knot...

Testing non-inferiority in active-controlled clinical trials examines whether a new procedure is, to a pre-specified amount, no worse than an existing procedure. To assess non-inferiority between two procedures using clustered matched-pair binary data, two new statistical tests are...

In this paper, the likelihood function and the posterior density function for the parameters given a symmetric trimmed sample are derived. It is assumed that the sample follows the half-normal model. By making use of the Bayesian framework, the predictive density for a single future response is...

Data, collected to model risk of an interesting event, often have a multilevel structure as patients are clustered within larger units, e.g. clinical centers. Risk of the event is usually modeled using a logistic regression model, with a random intercept to control for heterogeneity among...