Neocortical slices of mice were evaluated as a potential model for epilepsy. These slices spontaneously generate rhythmically occurring bursts of electrical activity in cortical neurons, which can be simultaneously recorded intracellularly and extracellularly. Blockade of GABAergic inhibition...

Animals respond to changes in their environment based on the information encoded in neuronal spike activity. When exploring the neural substrates of behaviors such as prey detection or predator avoidance, one key issue is to determine how quickly and reliably the system can detect that a...