In the simultaneous estimation of a large number of related quantities, multilevel models provide a formal mechanism for effciently making use of the ensemble of information for deriving individual estimates. In this article we present a novel and flexible class of normal multilevel models,...

Recombinant inbred lines (RILs) can serve as powerful tools for genetic mapping. Recently, members of the Complex Trait Consortium have proposed the development of a large panel of eight-way RILs in the mouse, derived from eight genetically diverse parental strains. Such a panel would be a...

Complementary DNA (cDNA) microarrays are a powerful tool for genomic analysis, but have noise components that make inferences regarding gene expression inefficient and potentially misleading. Background fluorescence, whether attributable to non-specific binding or other sources, is an important...

Cross-study validation of gene expression investigations is critical in genomic analysis. We developed an R package and associated object definitions to merge and visualize multiple gene expression datasets. Our merging functions use arbitrary character IDs and generate objects that can...

Over 10% of the data sets catalogued in the Gene Expression Omnibus Database involve messenger RNA samples that have been pooled prior to hybridization. Pooling affects data quality and inference, but the exact effects are not yet known as pooling has not been systematically studied in the...