In this note we outline 15 years of Gynecologic Oncology Group (GOG) experience conducting a series of phase II second-line intraperitoneal trials in the treatment of ovarian cancer. Using this information, the goal is to define a new permutation approach to historical control phase II trials in...

The aim of this paper is to study the effect of management factors on enterprise performance, considering a survey that the University Consortium in Engineering for Quality and Innovation has led. The relationships between management factors and enterprise performance are formalized by a...

We develop an autoregressive integrated moving average (ARIMA) model to study the statistical behavior of the numerical error generated from three fourth-order ordinary differential equation solvers: Milne's method, Adams-Bashforth method and a new method that randomly switches between the Milne...

This paper presents a Bayesian-hypothesis-testing-based methodology for model validation and confidence extrapolation under uncertainty, using limited test data. An explicit expression of the Bayes factor is derived for the interval hypothesis testing. The interval method is compared with the...

In disease screening and diagnosis, often multiple markers are measured and combined to improve the accuracy of diagnosis. McIntosh and Pepe [Combining several screening tests: optimality of the risk score, Biometrics 58 (2002), pp. 657-664] showed that the risk score, defined as the probability...

The primary purpose of this paper is to comprehensively assess households' burden due to health payments. Starting from the fairness approach developed by the World Health Organization, we analyse the burden of healthcare payments on Italian households by modeling catastrophic payments and...

There are a number of approaches to detect candidate gene-disease associations including: (i) 'per-genotype', which looks for any difference across the genotype groups without making any assumptions about the direction of the effect or the genetic model; (ii) 'per-allele', which assumes an...

In this paper we consider and propose some confidence intervals for estimating the mean or difference of means of skewed populations. We extend the median t interval to the two sample problem. Further, we suggest using the bootstrap to find the critical points for use in the calculation of...

Leverage values are being used in regression diagnostics as measures of influential observations in the $X$-space. Detection of high leverage values is crucial because of their responsibility for misleading conclusion about the fitting of a regression model, causing multicollinearity problems,...

Microtubules are part of the structural network within a cell's cytoplasm, providing structural support as well as taking part in many of the cellular processes. A large body of data provide evidence that dynamics of microtubules in a cell is reponsible for the performance of many critical...