We set out IDR as a loglinear-model-based Moran's I test for Poisson count data that resembles the Moran's I residual test for Gaussian data. We evaluate its type I and type II error probabilities via simulations, and demonstrate its utility via a case study. When population sizes are...

When thousands of tests are performed simultaneously to detect differentially expressed genes in microarray analysis, the number of Type I errors can be immense if a multiplicity adjustment is not made. However, due to the large scale, traditional adjustment methods require very stringen...

When the total amount of a mixture of ingredients needs to be taken into account (in addition to the composition of its ingredients), an experimental design requires several levels of the amount. Designs for such situations are discussed, and D-optimal choices are made for fitting quadratic and...

This paper describes the rigorous asymptotic distributions of the recently introduced partial directed coherence (PDC) - a frequency domain description of Granger causality between multivariate time series represented by vector autoregressive models. We show that, when not zero, PDC is...

In conjunction with TIMET at Waunarlwydd (Swansea, UK) a model has been developed that will optimise the scheduling of various blooms to their eight furnaces so as to minimise the time taken to roll these blooms into the finished mill products. This production scheduling model requires reliable...