In this paper, it is presented the polynomial form of multivariable generalized predictive control with multiple reference model (MIMO GPC⧸MRM). A new choice of the reference model is given which allows to obtain decoupled and smooth nominal output responses. Then the equivalent polynomial...

The high cell density cultivation (HCDC) of genetically modified microorganisms, e.g. E. coli, with dry weight larger than 100 g⧸l, requires fed-batch processing with aid of a controlled specific growth rate μ. A general mathematical model of HCDC as well as different methods to control μ is...

A distributed parameter fixed-bed bioreactor model with axial diffusion is presented. An orthogonal collocation method is applied to obtain a lumped parameter model, i.e. a system of ordinary differential equations, which consists of one subset for the biomass concentration and the other for the...

An expert system for the numerical integration of the phase shift problem of the one-dimensional Schrödinger equation is proposed in this paper.

Newton—Raphson's method plays a fundamental role in the maximum likelihood estimation of the two parameters of the Weibull probability distribution. It is well known that the method depends on the initial point of the iterative process and the iteration does not always converge.

We describe a newly established research project called SoftLab in the area of computational science and computational engineering. The SoftLab project attempts to link physical laboratory experimentation with computer control and simulation to provide a virtual laboratory for computational...

Our goal is the integration of accurate scientific computation and intelligent object-oriented techniques to obtain powerful tools that can be used for the successful development of scientific expert systems, i.e. systems which provide expertise in the choice of algorithms within a particular...

Much reusable software is available for solving routine mathematical and statistical problems. Unfortunately, locating this software is often quite difficult in current distributed computing environments. The Guide to Available Mathematical Software (GAMS) virtual software repository seeks to...

Cascade control configurations offer interesting possibilities to improve the control of processes. However, the tuning of cascade controllers can be quite complex, which hampers a wider spread of applications. Using an on-line pattern recognition approach and fuzzy inferencing it is possible to...

In industrial applications of process control, we can find a very large variety of supervision structures including diagnosis and prognosis techniques. Here, we are concerned with the problem of reconfigurable control systems that possess the ability to accommodate failures. After some general...