Diagrammatic modelling representation methods in discrete event simulation are varied and can be classified as follows: simulation strategy neutral, simulation strategy oriented, simulation language oriented, and methods borrowed from other computer modelling areas. The main diagrammatic methods...

A simulation of hybridoma cell growth and antibody production has been developed. It is capable of simulating all major metabolic variables of interest in batch and continuous culture and is the most complete reported to date.

A Taylor series technique for obtaining pointwise bounds for the solution of a class of diffusion problems in physiology is presented. Simple analytic bounding functions are obtained using an integral representation for the solution. Computations are performed in interval arithmetic, and thus...

A new numerical algorithm is introduced to solve the diffusion-migration-convection equations in electrochemistry. The constrained evolution equations are solved by a fractional step approach to decouple the nonlinear interactions of ions. The algorithm composes of a diffusion step, a step for...