The problem of identifying differentially expressed genes in designed microarray experiments is considered. Lonnstedt and Speed (2002) derived an expression for the posterior odds of differential expression in a replicated two-color experiment using a simple hierarchical parametric model. The...

Partial Least Squares (PLS) dimension reduction is known to give good prediction accuracy in the context of classification with high-dimensional microarray data. In this paper, the classification procedure consisting of PLS dimension reduction and linear discriminant analysis on the new...

van der Laan and Dudoit (2003) provide a road map for estimation and performance assessment where a parameter of interest is defined as the risk minimizer for a suitable loss function and candidate estimators are generated using a loss function. After briefly reviewing this approach, this...

A common experimental strategy utilizing microarrays is to develop a signature of genes responding to some treatment in a model system, and then ask whether the same genes respond in an analogous way in a more natural and uncontrolled environment. In statistical terms, the question posed is...

Visualisation methods for exploring microarray data are particularly important for gaining insight into data from gene expression experiments, such as those concerned with the development of an understanding of gene function and interactions. Further, good visualisation techniques are useful for...

Gene expression microarrays have become powerful tools in many areas of biological and biomedical research. These technologies allow researchers to measure the expression levels of thousands of genes in a tissue or cell sample simultaneously. One of the most common types of microarray...

Transcription factor binding site (TFBS) detection plays an important role in computational biology, with applications in gene finding and gene regulation. The sites are often modeled by gapless profiles, also known as position-weight matrices. Past research has focused on the significance of...

Two channel microarray data often contain systematic variations that can be minimized by data transformation prior to further analysis. The most commonly observed effects are revealed by viewing scatter plots of the logarithm of the ratio by the average logarithmic intensity of the two color...

We describe the use of a statistical model in a genome-wide microarray-based yeast genetic screen performed by imposing different genetic selections on thousands of yeast mutants in parallel. A mixture model is fitted to data obtained from oligonucleotide arrays hybridized to 20-mer...