Background: Over four millions people in England are estimated to have a CVD and they are responsible for over one third of deaths and a fifth of hospital admissions in England every year. In prioritising the reduction of premature mortality there has been a focus on improving prevention and...

Objectives: To report on the relative cost-effectiveness of total hip arthroplasty and resurfacing arthroplasty (replacement of articular surface of femoral head only) in patients with severe arthritis suitable for hip joint resurfacing arthroplasty. Design: Cost-effectiveness analysis (cost per...

The widely used proportional odds model is developed for correlated repeated ordinal score data, using a modified version of the generalized estimating equation (GEE) method for model fitting for a range of working correlation models. The algorithm developed estimates the correlation parameter,...