There is a need to extrapolate from in vitro concentrations to in vivo dose. To do this extrapolation it is necessary to be able to calculate free concentrations in both systems and then compare them. Concerning the in vitro side, in the first part of this work, we had developed and implemented,...

There is a need to integrate existing in vitro dose-response data in a coherent framework for extending their domain of applicability as well as their extrapolation potential. This integration would contribute towards the reduction of animal use in toxicology by using in vitro data for...