In many areas of pharmaceutical research, there has been increasing use of categorical data and more specifically ordinal responses. In many cases, complex models are required to account for different types of dependences among the responses. The clinical trial that is considered here involved...

Many of the repeated-measures sample size calculation methods presented in the literature are not suitable when: ” the different treatments are assumed to be equal on average at baseline time due to randomization, ” and the experimenters are interested in a pre-specified difference to be...