Background – Reliable and valid hospital nurse staffing measures are a major requirement for health services research. As the use of these measures increases, discussion is growing as to whether current nurse staffing measures adequately meet the needs of health services researchers. Objective...

In this paper we present a discussion of a phenomenological model of the MAPK cascade which was originally proposed by Angeli et al. [D. Angeli, J.E. Ferrell, Jr., E.D. Sontag, PNAS 101 (2004), 1822]. The model and its solution are extended in several respects: (a) an analytical solution is...