Abstract Purpose : Observational studies designed to investigate the safety of a drug in a postmarketing setting typically aim to examine rare and non-acute adverse effects in a population that is not restricted to particular patient subgroups for which the therapy, typically a drug, was...

This article dvelops a framework for understanding how financial and nonfinancial incentives can complicate point-of-care decision making by physicians, leading to the over- or under-use of health care services. The analysis highlights contributing factors that promote and impede evidence-based...

This “Methods to Policy†piece discusses opportunities and challenges in reconciling increased demands for evidence to be “patient-centered†with the realities of highly diverse patient circumstances, preferences, and clinical situations.

Background In the last decade, network meta-analysis of randomized controlled trials has been introduced as an extension of pairwise meta-analysis. The advantage of network meta-analysis over standard pairwise meta-analysis is that it facilitates indirect comparisons of multiple interventions...