Background Palbociclib and Ribociclib are cyclin-dependent kinase 4/6 oral molecular inhibitors that have the potential to improve overall survival (OS), progression-free survival (PFS), and quality of life in patients with metastatic breast cancer (MBC). The objective of this study was to...

The concept of agriculture has changed over the years. Whereas it was once considered simply a "means" for the production of goods (food and non-food), today, its multifunctionality, understood as the ability to also provide environmental and social services, takes on greater importance. The...

Do 'local' methods of evaluation, such as partial equilibrium analysis at market prices or estimation of shadow prices, provide reliable assessments of a large rural roads programme's social profitability? Consider a small open economy with one city and a rural hinterland, two traded goods, two...

Cryostorage of human embryos produced during the course of in vitro fertilization (IVF) treatment is an important issue for hospitals, governments and individuals who are facing fertility challenges. Embryo cryostorage is giving rise to increasing economic, ethical and legal concerns due to the...

The use of technologies that automate handling goods and loading units in warehouses and depots is not new. Yet, the purchase process of these technologies issues troubles and the estimation of the economic advantages brought by one or another technology to the entire chain of operations in...